The 2021 NCAA Tournament figures to be unlike any other event the sport has had.

Well-known blue bloods Kentucky and Duke are not in the field, Gonzaga is attempting to become the first unbeaten team in the sport since 1976, and the entire tournament will be played in Indiana, due to COVID-19 protocols. 

Through it all, we’re betting on every single game against the spread (ATS), with odds courtesy of FOX Bet, starting with the first round.

You read that right: Every. Single. Game. From the First Four to the championship, we have you covered with how to bet all of the matchups.

Now, come get some winners (with all odds via FOX Bet):

WEST REGION

No. 16 Norfolk State (+2.5) vs. No. 16 Appalachian State (First Four matchup to face No. 1 Gonzaga)

Lean to Appalachian State in the First Four after their miraculous run to the Sun Belt title, knocking off the two best seeds to go dancing for the first time since 2000. The Zags are the first team to enter the tournament undefeated since Kentucky in 2015, and the Jalen Suggs-led WCC champs are attempting to become the first unbeaten team in college basketball since Indiana in 1976. Gonzaga has won 23 straight games by double figures, and that continues with an easy win over Appalachian State.Pick: Appalachian State -2.5

No. 2 Iowa (-15) vs. No. 15 Grand Canyon University

Bryce Drew, the first-year coach for the Antelopes, is a March Madness legend dating to his buzzer-beater for Valpo. Iowa’s weakness is defending the 3-pointer, but the Antelopes are 245th in the country on 3s. Don’t overthink it.Pick: Iowa -15

No. 3 Kansas (-11) vs. No. 14 Eastern Washington

This is not a typical Bill Self team with a lottery pick. The Jayhawks are an elite defensive team, but because of COVID-19 ⁠— which cut their Big 12 tourney short ⁠— it’s unclear who will be available for their first-round game vs. the Eagles.Pick: Eastern Washington +11

No. 4 Virginia (-8) vs. No. 13 Ohio

Ohio has been terrific ATS this year (14-7), and the Bobcats have lost just once in the past seven weeks. Led by guard Jason Preston, the Bobcats nearly beat Illinois in November. Virginia was once 11-2 but has only one win over a tournament-bound team (Syracuse) in the past month. This opened with the Cavs as double-digit favorites, and it was quickly bet down. Sprinkle some on the money line.Pick: Ohio +8

No. 5 Creighton (-6.5) vs. No. 12 UC Santa Barbara

A 12-seed has beaten a 5-seed in 35 of the past 40 tournaments. In 13 of those 40 years, at least two No. 12 seeds have defeated No. 5 seeds. The Gauchos put up gaudy numbers in the Big West but haven’t defeated a tourney team. Creighton opened as a double-digit favorite, and it was immediately bet down.Pick: UCSB +6.5.

No. 11 Wichita State (-2) vs. No. 11 Drake (First Four matchup to face No. 6 USC)The Trojans feature potential No. 1 pick candidate Evan Mobley, who will remind some folks of Kevin Garnett or Chris Bosh. The problem? USC doesn’t have much else. I believe Drake (20-6-1 ATS) advances vs. Wichita State, and I’ll consider backing them vs. the Trojans if Drake’s best post presence, Shanquan Hemphill, returns from injury.Pick: Drake +2

No. 7 Oregon (-6) vs. No. 10 VCU

As usual, the Rams play outstanding defense ⁠— 12th in the country ⁠— but they have been destroyed on the defensive glass all season (289th in the nation), which means a potentially big game for Oregon’s Eugene Omoruyi and LJ Figueroa inside.Pick: Oregon -6

No. 8 Oklahoma (-2) vs. No. 9 Missouri

The Sooners limp in, having lost five of six, but four of those came against teams seeded fourth or higher in the tournament. Oklahoma’s offense flows through senior Austin Reaves, but defensively, the Sooners do a terrible job against 3-pointers (256th in the country). Fortunately, Missouri ⁠— which has beaten one NCAA Tournament team in the past five weeks ⁠— is a poor 3-point shooting team (254th).Pick: Oklahoma -2

EAST REGION

No. 16 Mt. St. Mary’s (+1) vs. No. 16 Texas Southern (First Four matchup to face No. 1 Michigan)

Gotta roll with Mt. St. Mary’s if only to root for 5-foot-8 point guard Damian Chong Qui, the 15-point per-game scorer who played every minute of the Mountaineers’ past five games, two of which went to overtime. The top-seeded Wolverines are susceptible — but not to the winner of this game. The injury to second-leading scorer Isaiah Livers is significant for Michigan, but the Wolverines should cruise by Mt. St. Mary’s.Pick: Mount St. Mary’s +1

No. 2 Alabama (-16.5) vs. No. 15 Iona

The Tide are 18-0 when they score 80 points. They’ve won six in a row and nine of 10. We have a great coach (Nate Oats), a senior leader (Herbert Jones) and a promising lead point guard in Villanova transfer Jahvon Quinerly. The Gaels have played only 17 games, and they’re not good defensively (161st) or offensively (210th).Pick: Alabama -16.5

No. 3 Texas (-9) vs. No. 14 Abilene Christian

Terrific backcourt, two NBA lottery picks and a coach in Shaka Smart who knows something about the Final Four. My only concern: The Longhorns are turnover-prone, and Abilene Christian forces more turnovers than anyone in America.Pick: Texas -9

No. 4 Florida State (-11) vs. No. 13 UNC Greensboro

The Spartans don’t have a win over a tournament team and aren’t in the top 100 offensively. They’re 312th in 3-point shooting and 255th in free throw shooting. Seminoles roll.Pick: FSU -11

No. 5 Colorado (-4.5) vs. No. 12 Georgetown

The Hoyas’ run to the Big East title was incredible, but the Buffaloes are better than all of those opponents. Colorado has a guard ⁠— McKinley Wright ⁠— and an efficient offense that is second in the country in free-throw shooting and has eight wins over tourney teams.Pick: Colorado -4.5

No. 11 Michigan State (-2) vs. No. 11 UCLA (First Four matchup to face No. 6 BYU)

Michigan State has the worst ATS of any team in the tournament (9-18). Sure, the Spartans have beaten No. 1 seeds Michigan and Illinois, but they have been woefully inconsistent on offense all season. UCLA is the same boat. If you’re going to pick a First Four team to win two games, ride the Spartans over the Bruins, then the BYU Cougars.Pick: Michigan State -2

No. 7 UConn (-2.5) vs. No. 10 Maryland

Darkhorse alert ⁠— the Huskies are 16-5-1 ATS this year, third in the country. When in doubt, roll with the best player on the floor, and that’s lottery pick James Bouknight, one of the most explosive scorers in the sport.Pick: Connecticut -2.5

No. 8 LSU (-1.5) vs. No. 9 St. Bonaventure

Few teams can tout three future pros ⁠— Javonte Smart, Cameron Thomas, Trendon Watford ⁠— but the Tigers have the offensive potential to make a Final Four run. The problem is, their defense is abysmal. The Bonnies don’t have a senior or much depth, so let’s see how their top-20 defense holds up against LSU.Pick: LSU -1.5

SOUTH REGION

No. 1 Baylor (-24) vs. No. 16 Hartford

I think the Bears are the second-most likely No. 1 seed to reach the Final Four. The only question here is whether the Bears touch 90 for the eighth time this season.Pick: Baylor -24.

No. 2 Ohio State (-17) vs. No. 15 Oral Roberts

The Buckeyes played four close games in the Big Ten tournament, including two that went to overtime. Don’t be surprised if Oral Roberts, led by Max Abmas, the nation’s leading scorer (24.3 PPG) hangs around for a bit. But they’re too putrid defensively (285th in the country) to win outright.Pick: Oral Roberts +17

No. 3 Arkansas (-9.5) vs. No. 14 Colgate

One of my first bets of the tournament was the over (162). Did Colgate put up elite stats (third in the country in 3-pointers, fifth in effective FG%) against a 15-game schedule in which it didn’t face one team in the Ken Pom Top 150? No 14-seed has beaten a 3-seed in the past three tournaments.Pick: Arkansas -9.5

No. 4 Purdue (-7.5) vs. No. 13 North Texas

The Mean Green had a tough nonconference schedule ⁠— Arkansas, West Virginia, Loyola Chicago ⁠— so they’ll be ready for Purdue. North Texas starts five seniors, and Purdue has no seniors. The difference will be Purdue’s 6-foot-10 Trevion Williams, who had 10 double-doubles this season.Pick: North Texas +7.5

No. 5 Villanova (-6) vs. No. 12 Winthrop

The Wildcats lost their leader, senior point guard Collin Gillespie, less than two weeks ago and have lost two close games since. Limited offensively, the 23-1 Eagles should be able to hang around and make it interesting, thanks to Chandler Vaudrin, who leads the country in triple-doubles. Winthrop hasn’t won an NCAA Tournament game since 2007.Pick: Winthrop +6

No. 6 Texas Tech (-4.5) vs. No. 11 Utah State

The Red Raiders have the talent, coaching and experience to make a Final Four run. But this a tough draw. I took the under (132) in what should be a low-scoring affair between two top-25 defenses.Pick: Texas Tech -4.5

No. 7 Florida (PK) vs. No. 10 Virginia Tech

The Gators have lost three of four and haven’t beaten a tourney team since Jan. 30. Virginia Tech has played only five games since Feb. 1 because of COVID-19.Pick: Florida pick’em

No. 8 North Carolina (-2) vs. No. 9 Wisconsin

The Badgers have lost six of eight. In their past seven games against NCAA Tournament teams, they’re 0-7. This figures to be a rock fight, as UNC can be anemic offensively (270th in 3-pointers, 207th in 2-pointers). Look hard at the under.Pick: UNC -2

MIDWEST REGION

No. 1 Illinois (-21.5) vs. No. 16 Drexel

The Illini have lost once in the past eight weeks and have perhaps the best 1-2 punch in the tournament in All-American guard Ayo Dosunmu and center Kofi Cockburn. Drexel is an elite 3-point-shooting team (37th in the country), but that’s the Dragons’ only hope to keep it close.Pick: Illinois -21.5

No. 2 Houston (-19.5) vs. No. 15 Cleveland State

The Cougars probably have the least respect among casual fans because they play in the AAC. But in a couple of games, Kansas transfer Quentin Grimes might be the best player you’d never heard of.Pick: Houston -19.5

No. 3 West Virginia (-12.5) vs. No. 14 Morehead State

The Mountaineers usually win with defense, but Bob Huggins’ offense this year is among the nation’s best (11th in efficiency). Quirky: They’re 291st in 2-point field goal percentage, but they dominate the offensive glass (13th in the nation) … so they score, anyway.Pick: Morehead State +12.5

No. 4 Oklahoma State (-9.5) vs. No. 13 Liberty

Bad job by the committee putting potential No. 1 pick Cade Cunningham in the most difficult quadrant, but the Cowboys should advance here against a Liberty team that put up impressive stats (top 10 in 3-point efficiency, 2-point efficiency) against a pitiful schedule.Pick: Liberty +9.5

No. 5 Tennessee (-7.5) vs. No. 12 Oregon State

The Beavers are lucky to be here after three stunning wins in the Pac-12 tournament. The Vols have two potential lottery picks in Keon Johnson and Jaden Springer.Pick: Tennessee -7.5

No. 6 San Diego State (-3) vs. No. 11 Syracuse

The Aztecs, who were 30-2 last season and poised to be a No. 1 seed, have won 14 straight this season and have the shooters to give Syracuse’s 2-3 zone problems. SDSU is 37th in the country in 3-point shooting, led by Jordan Schakel (46%) and Terrell Gomez (40%).Pick: SDSU -3

No. 7 Clemson (+2) vs. No. 10 Rutgers

A matchup of two top-20 defensive teams, which has me leaning to the under rather than a side. Clemson beat Purdue and Alabama in the nonconference, and Rutgers has beaten only one tourney team in this calendar year.Pick: Rutgers -2

No. 8 Loyola Chicago (-2) vs. No. 9 Georgia Tech

Perhaps the best first-round game. It’s criminal that the Ramblers ⁠— who went to the Final Four in 2018 ⁠— aren’t a higher seed. The Yellow Jackets are on a tear, having won eight straight, but they really struggle defending the 3-point line (307th in the country).Pick: Loyola -2

Jason McIntyre is a FOX Sports gambling analyst, and he also writes about the NFL and NBA Draft. He joined FS1 in 2016 and has appeared on every show on the network. In 2017, McIntyre began producing gambling content on the NFL, college football and NBA for FOX Sports. He had a gambling podcast for FOX, “Coming Up Winners,” in 2018 and 2019. Before arriving at FOX, he created the website The Big Lead, which he sold in 2010.