Covid-19: F.D.A. to Authorize Pfizer Vaccine for Adolescents by Early Next Week

on May4
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Thomas Gregory, 16, received a dose of the Pfizer coronavirus vaccine in Worcester, Mass., in April.
Credit…Joseph Prezioso/Agence France-Presse — Getty Images

The Food and Drug Administration is preparing to authorize use of the Pfizer-BioNTech coronavirus vaccine in adolescents 12 to 15 years old by early next week, according to federal officials familiar with the agency’s plans, opening up the U.S. vaccination campaign to millions more people.

Some parents have been counting down the weeks since Pfizer announced results from its trial in adolescents showing that the vaccine is at least as effective in that age group as it is in adults. Vaccinating children is key to raising the level of immunity in the population and bringing down the numbers of hospitalizations and deaths.

The clearance, in the form of an amendment to the existing emergency use authorization for the Pfizer vaccine, could come as early as late this week. If it is granted, the Centers for Disease Control and Prevention’s vaccine advisory panel is likely to meet the following day to review the clinical trial data and make recommendations for the vaccine’s use in adolescents.

The expansion would be a major development in the country’s vaccination campaign and welcome news to some parents who are anxious to protect their children during summer activities and before the start of the next school year. It also poses another challenge to policymakers who are struggling to vaccinate a large percentage of adults hesitant to get the shot. Many more could refuse to inoculate their children.

Pfizer reported several weeks ago that none of the adolescents in the clinical trial who received the vaccine developed symptomatic infections, a sign of significant protection. The company said that volunteers produced strong antibody responses and experienced about the same side effects seen in people ages 16 to 25.

Stephanie Caccomo, a spokeswoman for the Food and Drug Administration, said she could not comment on the timing of the agency’s decision.

“We can assure the public that we are working to review this request as quickly and transparently as possible,” she said.

Over 100 million adults in the United States have been fully vaccinated. But the authorization would arrive in the middle of a delicate and complex push to reach the 44 percent of adults who have not yet received even one shot.

With much of the world clamoring for the surplus of vaccines made in the United States, the Pfizer-BioNTech shot’s use in adolescents will also raise questions about whether the supply should be targeted to an age group that so far appears to be mostly spared from severe Covid-19.

The Food and Drug Administration’s authorization is likely to substantially ease concern among middle school and high school administrators planning for the fall. If students are able to be vaccinated by then, that could allow more normal gatherings and let administrators plan further ahead in the academic year.

The current vaccine supply in the United States is substantial. As of Monday, about 65 million doses had been delivered but not administered, including 31 million doses of Pfizer-BioNTech’s vaccine, nearly 25 million doses of Moderna’s and 10 million doses of Johnson & Johnson’s, according to figures collected by the C.D.C.

The Pfizer and Moderna vaccines both require two doses. Pfizer is authorized for ages 16 and up, while Moderna is authorized for ages 18 and up.

Tens of millions more Pfizer-BioNTech doses — about three weeks’ worth, according to one federal official — have been manufactured and are in various stages of readiness, awaiting final tests before being shipped.

Moderna expects results soon from its own clinical trial involving adolescents ages 12 to 17, followed by results for children 6 months to 12 years old later this year.

United States › United StatesOn May 3 14-day change
New cases 50,058 –26%
New deaths 751 –3%

World › WorldOn May 3 14-day change
New cases 682,232 +6%
New deaths 10,714 +12%

U.S. vaccinations ›

Where states are reporting vaccines given
Visitors at Times Square in Manhattan on Thursday.
Credit…Victor J. Blue for The New York Times

New York and its neighbors, New Jersey and Connecticut, will welcome back crowds on May 19, state officials said Monday, a major step for a region that was once a center of the coronavirus pandemic.

Restaurants, offices, retail stores, theaters, museums, barber shops, amusement parks and gyms and fitness centers will all be allowed to operate at full capacity for the first time since restrictions were adopted last year to prevent the spread of the virus.

Gov. Andrew M. Cuomo of New York announced the easing of pandemic restrictions on Monday as part of broader efforts to increase economic activities, including lifting curfews for food and beverage service. New York City will also return to 24-hour subway service on May 17.

“Today is a milestone for New York State and a significant moment of transition,” Mr. Cuomo, a third-term Democrat, said during a news conference in his Manhattan office.

Mr. Cuomo, in announcing the sweeping changes to pandemic restrictions, seemed to be trying to accelerate New York’s recovery and once again upstage his political rival, Mayor Bill de Blasio. Last week, the mayor had set a goal of July 1 for fully reopening the city.

Still, Mr. Cuomo acknowledged on Monday that immediately restarting operations might not make practical or economic sense for some businesses, such as Broadway theaters. Last week the Broadway League said theatrical performances there would likely not resume until September.

Businesses in New York will still have to abide by federal social distancing guidelines, which require a minimum of six feet of space between individuals.

So the size of crowds will still be limited by space constraints, but businesses won’t need to abide by the six-foot rule if they require that all individuals present proof of full vaccination or a negative coronavirus test result, Mr. Cuomo said. Restaurants can also get around the six-foot rule by erecting barriers between tables.

For people who have received the vaccine, Mr. Cuomo said, “life should be returning to normal. You’re vaccinated. And it’s an incentive to be vaccinated.”

The governor’s announcement came less than a week after Mr. de Blasio had announced that New York City would fully reopen by July 1, a proclamation that irritated Mr. Cuomo, who has the ultimate say over capacity restrictions in the state.

Mr. Cuomo’s announcement effectively fast-tracked the expected end to capacity restrictions by more than a month.

“As Mayor de Blasio declared, this will be the Summer of New York City,” Bill Neidhardt, the mayor’s press secretary, said after Mr. Cuomo’s announcement. “We look forward to seeing more details and are excited to have the city fully reopened in the summer.”

The Metropolitan Transportation Authority, which runs the city’s subway system, initially shut down subway service from 1 a.m. to 5 a.m. on May 6 last year as subway ridership plummeted in part as commuters avoided public transit and worked from home. M.T.A. crews were dispatched to deep clean and disinfect the subways during the closings.

But as recently as February, the M.T.A shortened the overnight subway closings to 2 a.m. to 4 a.m. and signaled that they soon planned to resume 24-hour service. M.T.A. officials said Monday that they planned to continue deep cleaning and disinfecting during subway operating hours. Recently, the C.D.C. acknowledged what scientists have been saying for months: The risk of catching the coronavirus from surfaces is low.

According to a New York Times database, the average number of new cases a day over the last two weeks has dropped by 44 percent or more in all three states, as of Monday. More than a third of each state’s population has been fully vaccinated, as of Monday.

But experts warn that in New York City, the slowing pace of vaccinations, the prevalence of under-vaccinated areas and the spread of worrisome variants mean that the pandemic is far from over.

Travelers at Seattle-Tacoma International Airport last month. The European Union says it will be open this summer to American travelers who have been fully vaccinated against Covid-19.
Credit…Ruth Fremson/The New York Times

The European Union will recommend that its member states open borders to travelers who have been fully vaccinated, it said on Monday, clearing the way for the countries to welcome more visitors.

Member states are set later this week to debate the proposal, which was issued by the European Commission, the bloc’s executive arm. Visitors who have received a vaccine approved by the European Union’s drug agency would be allowed to travel freely, and individual countries could still impose tougher requirements on visitors, the proposal said.

The Commission said that if certain member states were prepared to let in visitors who had tested negative, they should do the same for vaccinated ones. Unvaccinated travelers could still be permitted, but countries could require tests or quarantines.

Yet the return of tourism, which the European Commission’s president, Ursula von der Leyen, spoke about last Sunday, would be a much-needed boon for countries, particularly those in southern Europe whose economies rely heavily on tourism but have been crippled by shutdowns.

The announcement comes more than a year after the first bans on nonessential travel from most countries to the bloc came into effect.

A handful of countries with low virus caseloads, including Australia, New Zealand and South Korea, have been exempt from the ban. The Commission said on Monday that it would expand that list by allowing in visitors — regardless of vaccination status — from countries with virus rates higher than the current limit (though still lower than the European Union average).

If member states accept the proposal, they would also be able activate an “emergency brake” mechanism to suspend all travel from outside of the bloc, the Commission said, to avoid the spread of coronavirus variants.

Countries including Greece, Spain and France have already said they will open for visitors who can show proof of a vaccination or a negative test.

Under the new proposal, visitors would be able to enter the European Union if they received the last recommended dose of an authorized vaccine at least 14 days before arrival.

The policy switch was first previewed by Ursula von der Leyen, president of the European Commission, in an interview with The New York Times last month, during which she said that vaccinated Americans should be able to visit Europe this summer. The detailed proposal laid out on Monday also confirmed Ms. von der Leyen’s earlier statements about the important role that the mutual recognition of vaccination certificates will play in resuming international travel.

Oxygen cylinders outside a shop in South Delhi. A court said it would start punishing government officials for failing to deliver oxygen.
Credit…Atul Loke for The New York Times

A severe shortage of medical oxygen in India has left people gasping for their final breaths in their hospital beds, a sign of government futility in its fight against a crushing wave of coronavirus infections.

The latest tragic consequence came on Sunday night, when at least 12 people hospitalized with Covid-19 died in Chamarajanagar, southwestern India, because of a lack of oxygen, according to the regional authorities. Hospital officials were left desperately dialing senior government functionaries and made calls to neighboring officials for help. Videos from the hospital showed relatives of sick patients using towels to fan their loved ones in an attempt to save them.

Local officials provided different accounts of the death toll at the hospital. Some said that at least 10 died from oxygen deprivation. Others said that 14 more died after the accident but that they died of comorbidities related to Covid, not directly from the oxygen shortage.

Many countries, including Mexico, Nigeria, Egypt and Jordan, have faced oxygen shortages that have led to deadly accidents and driven up virus deaths. The World Health Organization estimated earlier this year that 500,000 people were in need of oxygen supply every day, but that number is likely to be much higher with the outbreak in India.

The Indian authorities have said that the country has enough liquid oxygen to meet medical needs and that it is rapidly expanding its supply. But production facilities are concentrated in eastern India, far from the worst outbreaks in New Delhi and in western areas of the country, requiring several days of travel by road.

Ritu Priya, a professor at the Center of Social Medicine and Community Health at Jawaharlal Nehru University in New Delhi, called the oxygen shortage a failure of governance. “We were not able to channelize oxygen distribution over the past year when that is what we should have been doing,” Dr. Priya said.

“We are living from oxygen cylinder to oxygen cylinder,” she said.

On Sunday, the New Delhi High Court said that it would start punishing government officials for failing to deliver oxygen after hospitals in the capital successfully sought an injunction, The Associated Press reported.

The Supreme Court also weighed in on Sunday, urging the central and state governments to consider another lockdown to gain control of the virus and to create an emergency stockpile of oxygen, according to the Indian news media.

Critics have blasted Mr. Modi’s handling of the crisis. A sudden, harsh lockdown imposed early in the pandemic sent millions of laborers scrambling back to their home villages and disrupted the economy. When cases dropped, Mr. Modi’s government failed to heed warnings of a potential resurgence from scientists, and its Covid-19 task force did not meet for months. Mr. Modi declared a premature victory over Covid in late January during what proved to be a mere lull in infections.

Now, cremation grounds are working day and night, burning thousands of bodies. The country is rife with the more lethal and transmissible B.1.1.7 variant of the coronavirus, first found in Britain, as well as a local variant, B.1.617. Experts are worried that the unchecked outbreak will spawn more dangerous variants of the coronavirus.

On Monday, the Indian federal Health Ministry reported 368,147 new cases and 3,417 deaths from the virus, a figure that generally remains low on the first day of the week. India reported new daily cases of as much as 392,488 on Saturday, a tally that no other country has ever seen. The real toll is far higher, according to experts.

Indian officials announced over the weekend that the army had opened its hospitals to civilians and that the first batch of the Russian vaccine, Sputnik V, had arrived, a boost to India’s flagging inoculation campaign.

Over the weekend, aid from a half-dozen countries arrived at airports across India; it included 157 ventilators from the United Arab Emirates, 500 oxygen cylinders from Taiwan and 1,000 vials of the medicine Remdesivir from Belgium.


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On Sunday, the United States delivered the third of six aid shipments to New Delhi, including 1,000 oxygen cylinders. Britain donated more than 400 oxygen concentrators, and France sent eight oxygen generators, each of which can serve 250 hospitalized patients.CreditCredit…Pool photo by Prakash Singh

Vaccines are badly needed in India, where shortages forced several states on Saturday to delay expanding access to everyone aged 18 and over. While it is a global power in vaccine production, India didn’t purchase enough doses to protect itself: Less than 2 percent of its 940 million adults have been fully vaccinated.

global roundup

A hospital in El Alto, Bolivia, hosted a vaccination day for older adults last week. A second batch of vaccines arrived in Bolivia through Covax, the international vaccine-sharing initiative.
Credit…Martin Alipaz/EPA, via Shutterstock

The American drugmaker Moderna announced on Monday that it would supply up to 500 million doses of its coronavirus vaccine to Covax, the international vaccine-sharing initiative that aims to distribute vaccines to poor and middle-income countries that have been unable to secure deals on their own.

Under the agreement, which was negotiated by Gavi, the Vaccine Alliance, the first 34 million doses will be delivered by the end of the year, and the rest through 2022.

The deal covers 92 middle- and low-income countries, Moderna said. It added that the doses would be offered at the company’s “lowest-tiered price” but did not say what that was.

The deal comes as countries in Europe have pledged donations to Covax to address urgent supply shortages, in particular with AstraZeneca vaccines manufactured in India, which has curtailed exports as it faces an unprecedented surge of infections.

Tedros Adhanom Ghebreyesus, the director of the World Health Organization, which backs Covax, said on Monday that the initiative urgently needed 20 million doses for the second quarter of 2021.

“Covax has now shipped almost 50 million doses of vaccine to 121 countries and economies, but we continue to face serious supply constraints,” Dr. Tedros said at a W.H.O. news conference. “Solving this dilemma demands courageous leadership from the world’s largest economies.”

Sweden announced that it would donate a million AstraZeneca doses to Covax to address shortages, and France made an initial pledge of 500,000 last month.

Although Covax was created to resolve the inequities created by a free market where the richest can buy the most, it has delivered only 49 million doses to dozens of countries, according to Gavi’s website. Health advocates have questioned its transparency and accountability, and developed countries have been accused of cutting lines and monopolizing vaccine doses.

In other news from around the world:

  • Denmark will not use the Johnson & Johnson vaccine, the Danish Health Authority announced on Monday, saying in a statement that the country could make adequate progress using other vaccines and did not need to run the risk of a rare, dangerous blood clotting condition that may be linked to the Johnson & Johnson vaccine. Dropping the vaccine from its plans will set back the country’s timetable for vaccinating adults under 40 by about a month, Danish officials said.

  • Public fury over Nepal’s growing virus wave has been rising in the country, with many people blaming travelers from India and several other virus-stricken countries as well as government ineptitude in handling the pandemic and large political rallies. In response, Nepal halted all domestic flights on Sunday and announced that it would suspend international flights starting Wednesday.

  • To prevent a new wave of infections in Australia, about 8,000 Australia citizens and residents are banned from returning home from India as of Monday.

  • In Britain, a group of cross-party lawmakers urged the government on Monday to discourage all leisure travel abroad to prevent the importation of new variants into Britain and to reduce the risk of a new wave of infections. The warning comes as Prime Minister Boris Johnson plans to reopen international travel this month, with many in Britain hoping that they can travel across Europe and beyond for summer vacation.

  • In the Philippines, President Rodrigo Duterte appeared to receive his first dose of the Sinopharm coronavirus vaccine on Monday, according to a livestream shared on Facebook by a Filipino lawmaker and Filipino news outlets. “I feel good,” Mr. Duterte said in the video, adding that he had been expecting to receive the China-backed vaccine for a long time. The vaccine has not been approved by the World Health Organization for emergency use yet, and Sinopharm has not applied for approval by the Philippine drug regulator. But Mr. Duterte received it under a permit that granted access to 10,000 doses for his security group, according to Rappler, a Manila-based news website.

  • In Greece, outdoor restaurant service resumed on Monday after a six-month hiatus, a much-anticipated reopening after people began filling city squares and beaches as temperatures rose. Greece has gradually lifted restrictions in recent weeks, including ending quarantine requirements for visitors from dozens of countries. The authorities plan to reopen the tourism sector on May 15, when domestic travel restrictions are also set to lift.

  • France began easing lockdown restrictions on Monday, reopening middle and high schools and lifting a ban on domestic travel. Outdoor dining at cafes and restaurants is scheduled to reopen later this month, and a 7 p.m. nightly curfew is expected to be pushed back to 9 p.m.

  • The European Union’s drug regulator announced that it had begun evaluating clinical-trial data to extend the authorization of the Pfizer-BioNTech coronavirus vaccine to children ages 12 to 15, the first vaccine to be assessed for pediatric use in the bloc. The European Medicines Agency said the review would be accelerated, and it expects a decision in June.

  • In Germany, the Munich Oktoberfest will be canceled for a second year in a row, the authorities in the Bavaria region said on Monday. The lawmakers cited difficulties in enforcing mask or distance rules. The last time the event ran, in September and October 2019, it attracted 6.3 million people.

  • In a bid to improve their customer service at vaccination centers, officials in Mexico City have cued up entertainment performances — including large, bare-chested Lucha Libre wrestlers doing the limbo and men performing tricks with a surprising number of soccer balls — for those waiting for their shots.

  • President Iván Duque of Colombia said he would withdraw a plan to overhaul the tax system to plug a fiscal shortfall caused by the pandemic after at least 17 people were killed and hundreds injured in protests against his plan. The finance minister said he would resign on Monday.

Janice K. Jackson, the C.E.O. of the Chicago Public Schools, has decided to leave her post in June, meaning Chicago, New York City and Los Angeles will all see a change in school leadership.
Credit…Pool photo by Shafkat Anowar

The chief executive officer of the Chicago Public Schools, Janice K. Jackson, will leave her job at the end of June, she said on Monday.

Her departure will mean new leaders will take over all three of the largest U.S. school districts — New York City, Los Angeles and Chicago — as the districts try to fully reopen schools and recover from the extreme disruption of the pandemic.

The superintendent of the Los Angeles Unified School District, Austin Beutner, said recently that he would also step down at the end of June.

Earlier this year, Richard A. Carranza, the former New York City schools chancellor, resigned and was replaced by Meisha Porter, a longtime New York City educator and the first Black woman to lead the nation’s largest school system. With New York City electing a new mayor later this year, it is unclear if the next mayor will keep Ms. Porter in the role.

The pandemic has put superintendents in the middle of local battles over school reopenings, and many are exhausted. Across the country, many district leaders are retiring or resigning this year.

The path to reopening in Chicago was particularly fraught, with the teachers’ union clashing with Dr. Jackson and Mayor Lori Lightfoot over the conditions for having students back in classrooms. All students in Chicago became eligible to attend school in-person beginning on April 19, but many are able to attend only part-time, and a majority of families chose to keep their children learning remotely for the rest of the year.

Dr. Jackson was educated in the Chicago Public Schools and has worked for the district for 22 years, as a teacher, principal and chief education officer before becoming C.E.O.

“As I look back on what we’ve done, I am both proud and humbled, and also a little tired if I’m being honest,” she said.

She said she would spend her remaining time starting programs to address the challenges students have faced during the pandemic and making sure that the district has solid plans for students to attend school full-time in the fall.

Lining up for Covid-19 vaccines in Toronto in April.
Credit…Chris Helgren/Reuters

Naomi Harris plans to drive to Buffalo next week from her home in Toronto to get the second dose of the Pfizer coronavirus vaccine. At home, her second appointment was set for July 1, but she thought that as a caregiver for someone with cancer, that was too long to wait.

Canada’s slow vaccine rollout has left some people waiting four months between doses. While at least 33 percent of Canadians have received one shot, just three percent are fully vaccinated.

New daily cases reached a seven-day average over 8,700 in mid-April, according to a New York Times database, levels not seen since a winter surge. Ontario has been among the hardest hit, reporting 3,700 new cases on Sunday.

Ms. Harris, 47, said she had to be “very pushy” for her mother to get vaccinated in a shorter time than expected. After her mother received a first dose in early March, her second dose was scheduled for June 30, according to Ms. Harris, “which was insane because my mom has cancer and is over 80,” she said.

Eventually, their province of Ontario changed the rules for people with certain types of cancer and Ms. Harris’s mother received her second dose in early April. Ms. Harris is eligible for her shot in Buffalo as a dual Canadian and American citizen who is enrolled in a graduate program in Buffalo remotely. “I can’t take the risk of getting my mom sick,” Ms. Harris said.

As supply increases, officials have said, the wait between two inoculations is expected to shorten, and some initiatives are trying to shrink the gap.

Zain Manji, who runs the company Lazer from Toronto, created a text system with a friend that allows people to find vaccination sites near them. Since its start on April 30, at least 50,000 people have used it.

“I think there’s been a lot of confusion around who is eligible, which locations are vaccinating people, what vaccines that they’re offering,” Mr. Manji said. “People are eager to get it and want to get it as fast as they can,” he added about the vaccine.

The vaccines are coming at a crucial time: Amid a third wave, the worst-affected provinces are reporting case numbers per capita that rival those of India — although figures in India are likely to be underestimated.

In Quebec, a curfew, limits on gatherings, and takeout-only dining have helped to quell cases. Jean-Sébastien Guay, 27, of Montreal had his first shot on Sunday. “It hasn’t been perfect,” he said, but officials communicated consistently. “They all work pretty hard to make it work.”

Peter Hotez, a vaccine expert at Baylor College of Medicine, has been pushing for the Biden administration to offer help to Canada. “This is not a time to hold back,” Dr. Hotez said in a telephone interview. After writing on Twitter that the government should ship more Pfizer doses to Canada, he was met with emotional stories from Canadians.

Adding insult to injury for some Canadians is the possibility of their country opening travel to vaccinated American tourists. “It’s frustrating for me to sit here and watch my friends in the United States going to restaurants, carrying on as if life is normal,” said Ms. Harris, who said she had been in a quasi-lockdown since November.

“In the rest of the world, life is not normal.”

A vaccination center in Bangkok. The world’s richest nations are vaccinating their populations at a much faster pace as the world’s poorest struggle to make a dent.
Credit…Adam Dean for The New York Times

More than 600 million people worldwide have been at least partly vaccinated against Covid-19 — meaning that more than seven billion have not. It is a striking achievement in the shadow of a staggering challenge.

Half of all the doses have gone into the arms of people in countries with one-seventh of the world’s people, primarily the United States and European nations. Dozens of countries, particularly in Africa, have barely started their inoculation campaigns.

As wealthy countries envision the pandemic retreating within months — while poorer ones face the prospect of years of suffering — frustration has people around the world asking why more vaccine isn’t available.

Nationalism and government actions do much to help explain the stark inequity between the world’s haves and have-nots. So, for that matter, does government inaction. And the power of the pharmaceutical companies, which at times seem to hold all the cards, cannot be ignored.

But much of it comes down to sheer logistics.

Immunizing most of humanity in short order is a monumental task, one never attempted before, and one that experts say the world wasn’t ready to confront. They note that things have already moved with unprecedented speed: A year and a half ago, Covid-19 was unknown, and the first vaccine authorizations came less than six months ago.

But there is a long way to go. Here is a look at the reasons for the vaccine shortfall.

A health worker administers a Covid-19 test in Gauhati, India, on Saturday.
Credit…Anupam Nath/Associated Press

The coronavirus surge that is lashing India, where countless funeral pyres cloud the night skies, is more than just a humanitarian disaster: Experts say uncontrolled outbreaks like India’s also threaten to prolong the pandemic by allowing more dangerous virus variants to mutate, spread and possibly evade vaccines.

The United States will begin restricting travel from India later this week, but similar limitations on air travel from China that President Trump imposed in the early days of the pandemic proved to be ineffectual.

“We can ban all the flights we want but there is literally zero way we can keep these highly contagious variants out of our country,” said Dr. Ashish Jha, the dean of the Brown University School of Public Health.

As the coronavirus spreads among human hosts, it invariably mutates, creating opportunities for new variants that can be more transmissible or even more deadly. One highly contagious variant, known as B.1.1.7, crushed Britain earlier this year and is already well entrenched in the United States and Europe.

Recent estimates suggest that B.1.1.7 is about 60 percent more contagious and 67 percent more deadly than the original form of the virus. Another worrisome variant, P.1, is wreaking havoc across South America.

On Friday, India recorded 401,993 new cases in a single day, a world record, though experts say its true numbers are far higher than what’s being reported. Peru, Brazil and other countries across South America are also experiencing devastating waves.

Virologists are unsure what is driving India’s second wave. Some have pointed to a homegrown variant called B.1.617, but researchers outside of India say the limited data suggests that B.1.1.7 may be to blame.

With 44 percent of adults having received at least one dose, the United States has made great strides vaccinating its citizens, though experts say the country is far from reaching so-called herd immunity, when the virus can’t spread easily because it can’t find enough hosts. Vaccine hesitancy remains a formidable threat to reaching that threshold.

In much of the world, however, vaccines are still hard to come by, especially in poorer countries. In India, less than 2 percent of the population has been fully vaccinated. “If we want to put this pandemic behind us, we can’t let the virus run wild in other parts of the world,” Dr. Jha said.

Preliminary evidence suggests that the vaccines are effective against the variants, although slightly less so against some.

“For now, the vaccines remain effective, but there is a trend toward less effectiveness,” said Dr. Céline Gounder, an infectious disease physician and epidemiologist at Bellevue Hospital in New York.

Vaccine makers say they are poised to develop booster shots that would tackle especially troublesome variants, but such a fix would be of little help to poorer nations already struggling to obtain the existing vaccines. Experts say the best way to head off the emergence of dangerous variants is to tamp down new infections and immunize most of humanity as quickly as possible.

Dr. Michael Diamond, a viral immunologist at Washington University in St. Louis, said that the longer the coronavirus circulates, the more time it has to mutate, which could eventually threaten vaccinated people; the only way to break the cycle is to ensure countries like India get enough vaccines.

“In order to stop this pandemic, we have to vaccinate the whole world,” Dr. Diamond said. “There will be new waves of infection over and over again unless we vaccinate at a global scale.”

A Covid-19 patient received oxygen from a gurdwara, or Sikh house of worship, last month.
Credit…Atul Loke for The New York Times

With India’s health care system overwhelmed by the country’s unprecedented Covid-19 surge, desperate relatives and friends of the infected have resorted to sending S.O.S. messages on social media.

Many of those calls are being answered.

More than 400,000 new coronavirus cases and thousands of deaths are being reported each day. Some people need medical oxygen, which is nearly impossible to find in Delhi, the capital. Others are hunting for medicine that is expensive on the black market, or for rare ventilators.

The pleas are reaching tech-savvy engineers, lawyers, employees of nongovernmental organizations, politicians, doctors and even tuk-tuk drivers, who have mobilized online to help the sick, some of them hundreds of miles away. They have formed grass-roots networks that are stepping in where state and national governments have failed.

India’s loose online aid networks rely on tools and techniques commonly used in marketing and other forms of messaging on social media. Families tag people with large followings or specialized skills who might be able to amplify their messages, while volunteer organizers use keywords to filter the flood of requests.

Over a thousand people gathered to watch the Stockyards Championship Rodeo in Fort Worth, Tex., last month.
Credit…Shelby Tauber for The New York Times

Early in the pandemic, when vaccines were still just a glimmer on the horizon, the term “herd immunity” came to signify the endgame: the point when enough Americans would be protected from the virus that we could be rid of it.

Now, more than half of adults in the United States have been vaccinated with at least one dose. But rates are slipping, and there is widespread consensus among public health experts that herd immunity is not attainable — not in the foreseeable future, perhaps not ever.

Instead, they are coming to the conclusion that the virus will most likely become a manageable threat that will continue to circulate in the United States for years, still causing hospitalizations and deaths but in much smaller numbers.

How much smaller depends in part on how much of the nation, and the world, becomes vaccinated and how the coronavirus evolves.

A woman pleaded for oxygen for her husband at a Sikh temple, in Ghaziabad, India, on Monday.
Credit…Adnan Abidi/Reuters

Savita Mullapudi, an international development consultant in Pittsburgh, heard the ping of a WhatsApp message on her phone around 4 p.m. on Thursday. The sender was a former colleague who, like her, was an Indian immigrant who had lived in the United States for years. He had an urgent favor to ask.

With India’s health care system overwhelmed by the nation’s unprecedented Covid-19 surge and hospitals running out of lifesaving oxygen, an Indian charity was scrambling to find oxygen concentrators, which filter oxygen from the air. One manufacturer was based in Pittsburgh. Could Ms. Mullapudi visit the site to vet the equipment?

Like many members of the Indian diaspora who have watched and mobilized from afar as a deadly second wave of the coronavirus has swept across India in recent weeks, Ms. Mullapudi, whose parents and in-laws live there, leapt at the opportunity to help. She called the company a few minutes later but was told the earliest date for a visit was May 8 — far too late.

So Ms. Mullapudi, 44, said she did “the next-best thing.” She asked a few local doctor friends to tap their networks in Pittsburgh and across Pennsylvania for their opinions of the company and the quality of its products.

By 9 a.m. the next day, she had received texts and long emails from medical professionals and hospital executives with “rave reviews” of the manufacturer, she recalled, as well as detailed descriptions of the machines’ electricity costs and how long they lasted.

Credit…Aria M. Narasimhan

“The minute I said ‘India Covid,’ I was inundated with responses,” Ms. Mullapudi said. “These networks of people that we all work with or know as friends just churned it around, and that’s what really gave the organization confidence to go ahead.”

Before noon on Friday, the foundation ordered more than 400 oxygen concentrators to be flown to India. Though Ms. Mullapudi described her role as just “one drop in an ocean,” she acknowledged the profound impact of so many small acts of human kindness in the face of such dire challenges.

“Eventually it’s just people helping people,” she said. “That’s the story of hope.”

Employees tested the procedures for making the Covid-19 vaccine at a BioNTech facility in Marburg, Germany in March.
Credit…Thomas Lohnes/Agence France-Presse — Getty Images

President Biden, faced with surging Covid-19 crises in India and South America, is under intensifying pressure from the international community and his party’s left flank to commit to increasing the vaccine supply by loosening patent and intellectual property protections on coronavirus vaccines.

Pharmaceutical and biotech companies, also feeling pressure, sought on Monday to head off such a move, which could cut into future profits and jeopardize their business model. Pfizer and Moderna, two major vaccine makers, each announced steps to increase the supply of vaccine around the world.

The issue is coming to a head as the World Trade Organization’s General Council, one of its highest decision-making bodies, meets Wednesday and Thursday. India and South Africa are pressing for the body to waive an international intellectual property agreement that protects pharmaceutical trade secrets. The United States, Britain and the European Union so far have blocked the plan.

Inside the White House, health advisers to the president admit they are divided. Some say that Mr. Biden has a moral imperative to act, and that it is bad politics for the president to side with pharmaceutical executives. Others say spilling closely guarded but highly complex trade secrets into the open would do nothing to expand the global supply of vaccines.

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